Analysis and manipulation of the genome-wide integration signatures of gamma-retroviral and lentiviral vectors in human haematopoietic stem cells [ 2012 - 2014 ]

Also known as: Detailed mapping and manipulation of gene therapy vector integration sites in human bone marrow stem cells to enhance safety

Research Grant

[Cite as]

Researchers: Prof Ian Alexander (Principal investigator) ,  Prof Marina Cavazzana-Calvo Prof Shoba Ranganathan

Brief description Gene therapy has been successful in treating several diseases involving the bone marrow, but has been associated with the development of leukaemia in a number of patients. The cause has been tracked to the gene transfer technology used and associated damage to the genetic blueprint of treated cells. In this study we plan to use high-throughput genetic analysis to better understand the nature of this damage and to develop strategies to improve the safety of the gene repair process.

Funding Amount $AUD 612,154.00

Funding Scheme Project Grants

Notes Standard Project Grant

Click to explore relationships graph
Viewed: [[ro.stat.viewed]]