Cytorefractometry - a new technique for refractive index tomography of living cells [ 2004 - 2008 ]

Research Grant

[Cite as]

Researchers Dr AV ZvyaginProf JH Campbell

Brief description An ultrahigh-resolution bifocal optical coherence refractometry is proposed, and will result to micron-scale-resolution refractive index tomography of living cells, termed cytorefractometry. This technique represents an extension from bifocal optical coherence refractometry that has recently shown a remarkable promise for direct, several-frames-per-second, motion-artifact-free determination of refractive index in turbid media, including biological tissue in vivo. We propose to apply our novel technique to study tissue calcification, a serious problem in cardiology, by making use of the refractive index contrast mechanism. Calcification of smooth muscle cells and aorta subdermal implant models will be studied aiming for prevention of calcification-associated pathologies.

Funding Amount $720,000

Funding Scheme Discovery Projects

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