Defining the role of plasminogen activation in group A streptococcal invasive disease [ 2011 - 2016 ]

Also known as: Plasminogen activation and group A streptococcal invasive disease

Research Grant

[Cite as]

Researchers: Dr Martina Sanderson-Smith (Principal investigator)

Brief description The "flesh-eating" bacteria group A streptococcus (GAS) causes life threatening invasive diseases such as necrotizing fasciitis and toxic shock syndrome (>600,000 cases and 163,000 deaths per year). For some types of GAS, plasminogen binding is essential for virulence.The aim of this work is to determine the extent to which plasminogen binding contributes to disease caused by highly virulent GAS. These studies will allow the development of new therapeutics and treatments.

Funding Amount $AUD 425,763.65

Funding Scheme Career Development Fellowships

Notes RD Wright Biomedical CDF

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