Determining the influences of cell stress and heat shock factor-1 action in osteoclast formation and pathological bone loss. [ 2014 - 2016 ]

Also known as: Does causing stress in a bone cause it to become weaker? The role of cell stress responses in inflammation-associated bone loss.

Research Grant

[Cite as]

Researchers: Dr Julian Quinn (Principal investigator) ,  A/Pr John Price Prof Matthew Gillespie

Brief description Cancer and rheumatoid arthritis cause painful bone destruction. This occurs due to increased numbers of bone destroying cells called osteoclasts. We found stress responses in bone cells can increase osteoclast numbers by activating proteins inside the bone cells that encourage osteoclasts to form. We will thus study whether cell stress blocking drugs might stop bone loss. As arthritis and cancer both cause stress responses, this work could identify a new way that such diseases affect bone.

Funding Amount $AUD 657,287.36

Funding Scheme Project Grants

Notes Standard Project Grant

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