grant

Discovery Projects - Grant ID: DP160101429 [ 2016 - 2023 ]

Research Grant

[Cite as http://purl.org/au-research/grants/arc/DP160101429]

Researchers Prof Ronald Quinn; Dr Ruangelie Edrada-Ebel

Brief description The project aims to transform the approach to identify novel biologically active compounds that occur in nature. For decades, natural product chemistry has centred on bio-assay guided isolation, but it has become increasingly difficult to isolate novel compounds. While de-replication strategies detect the presence of known compounds using databases, more impact would be achieved by directly detecting novel compounds. Nuclear magnetic resonance (NMR) spectroscopy detects every molecule that has a proton and is quantitative. This project plans to develop a NMR technique to escape bio-assay guided isolation by analysing a fraction library. Biotechnology innovation is dependent on novel compounds to provide new products. Replacing ‘grind and find’ with a technique that never lies would be transformational.

Funding Amount $493,300

Funding Scheme Discovery Projects

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