[Cite as http://purl.org/au-research/grants/arc/DP180100805]
Researchers Prof Nicholas Dixon; A/Prof Aaron Oakley; Dr Guido Pintacuda; Prof Elizabeth Harry; Dr Andrew Robinson; A/Prof Michael Kelso
Brief description This project aims to develop and use new technologies to address mechanistic aspects of anti-bacterial compounds in development, and of the development of resistance to them. The project will focus on the sliding clamp subunit of the bacterial replicative polymerase by studying its association with many other proteins in vitro and in vivo, using novel techniques in solid-state NMR, single-molecule fluorescence and molecular microbiology. The outcomes are expected to be an increased understanding of bacterial DNA replication and mechanisms of antibiotic action and resistance. This project expects to generate new knowledge to assist in combatting antibiotic resistance in Gram-negative bacterial pathogens.
Funding Amount $534,573
Funding Scheme Discovery Projects