grant

Estimation and partitioning of the still-missing heritability for complex disease [ 2013 - 2015 ]

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1050218]

Researchers: Prof Naomi Wray (Principal investigator) ,  Prof Jian Yang Prof Peter Visscher

Brief description We have pioneered the use of multi-marker statistical genetic methods in human genetics to elucidate the genetic architecture of complex traits, including common diseases. We have shown that between a third and a half of additive genetic variation is captured by common genetic variants, leaving two-thirds to a half truly ‘missing’. In this proposal we will test our hypothesis that the still-missing heritability is due to low frequency causal variants. Applications of genomic medicine require this fundamental knowledge to progress fully.

Funding Amount $AUD 291,856.83

Funding Scheme Project Grants

Notes Standard Project Grant

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