Function of matrix proteins important for storage and activation of TGF and TGF -induced tissue remodelling and repair [ 2008 - 2012 ]

Also known as: Proteins important for regulating activity and effects of growth factor TGF in tissue development and diseases

Research Grant

[Cite as]

Researchers: A/Pr Eric Hanssen Prof Robert Mecham (Participant) Dr Mark Gibson (Principal investigator)

Brief description The growth factor TGF is important for tissue development and repair, and in diseases such as pulmonary fibrosis, glomerulonephritis, liver cirrhosis, keloid formation and cancers. This project focuses on 2 important matrix proteins first discovered by Dr Gibson, LTBP-2 and ig-h3, that modulate TGF storage and TGF -induced tissue remodelling . We will use knock out mouse and cell culture models to determine the function of these proteins in tissue development and repair, and in diseases.

Funding Amount $AUD 690,875.75

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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