[Cite as http://purl.org/au-research/grants/arc/FT140100873]
Researchers Dr Francesca Cavalieri
Brief description In this research project Dr Cavalieri seeks to develop new miRNA-polymer nanoassemblies with enhanced bioresponsive properties. Nanoengineered functional RNA-polymer materials can exploit both the recognition properties of RNA and the responsiveness of the polymer to tailor the structural and physicochemical properties of such systems. Further, targeting ligands (antibody, aptamers) tethered to the RNA-polymer nanoassembly could augment cellular uptake and delivery. The development of imaging and tracking methodology to accurately measure intracellular miRNA payload and localization in 3D tissue mimicking matrix will be also achieved.
Funding Amount $772,104
Funding Scheme Future Fellowships