The Influence of NF-KB in the development of autoimmunity and cancer in Fas/FasL mutant mice [ 2011 - 2013 ]

Also known as: The role of NF-KB in the development of autoimmunity and tumourigenesis

Research Grant

[Cite as]

Researchers: Dr Lorraine O'Reilly (Principal investigator)

Brief description Apoptotic cell death is an essential process in the human body, it removes useless and dangerous cells, preventing autoimmune disease and cancer. Apoptosis is activated when the surface receptor Fas is stimulated by its ligand, FasL, but defective signalling causes disease associated with deregulated NF-?B activation. We will investigate how faulty FasL-induced apoptosis cooperates with deregulated NF-kB activation or defective Aire (immunological tolerance orchestrator) results in autoimmunity.

Funding Amount $AUD 596,925.50

Funding Scheme Project Grants

Notes New Investigator Grant

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