[Cite as http://purl.org/au-research/grants/nhmrc/1009145]
Dr Lorraine O'Reilly
Brief description Apoptotic cell death is an essential process in the human body, it removes useless and dangerous cells, preventing autoimmune disease and cancer. Apoptosis is activated when the surface receptor Fas is stimulated by its ligand, FasL, but defective signalling causes disease associated with deregulated NF-?B activation. We will investigate how faulty FasL-induced apoptosis cooperates with deregulated NF-kB activation or defective Aire (immunological tolerance orchestrator) results in autoimmunity.
Funding Amount $AUD 596,925.50
Funding Scheme Project Grants
New Investigator Grant