Interactions between aberrant transcriptional programs and methylation in primary myelodysplasia and leukaemia. [ 2014 - 2017 ]

Also known as: Deciphering transcriptional networks in blood stem cell disorders

Research Grant

[Cite as]

Brief description Impaired development of blood stem cells leads to haematological disease such as leukaemia. State of the art next-generation sequencing and bioinformatics identified molecular pathways essential for normal blood development and a core set of these genes repressed in leukaemia. Understanding the mechanism by which these genes are re-activated by the non-specific drug azacitidine contributes to the development of new therapeutics with increased efficiency and reduced side effects.

Funding Amount $AUD 316,449.66

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF

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