grant

Investigating the pathogenesis of motor neuron disease using zebrafish models [ 2012 - 2015 ]

Also known as: Zebrafish models of motor neuron disease

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1034816]

Researchers: A/Pr Ian Blair Dr Angela Laird Prof Garth Nicholson (Participant) Dr Nicholas Cole (Principal investigator)

Brief description Amyotrophic lateral sclerosis (ALS) causes the progressive death of motor nerves. Most ALS patients die within 2-5 years of disease onset. We recently identified mutations that cause ALS in the genes TDP-43 and FUS. We aim to develop fish that carry these mutations. We will monitor and test this fish to establish whether they develop similar symptoms and features to ALS. If so, this new fish model will be available for investigating the biology of the disease and for evaluating treatments

Funding Amount $AUD 554,881.53

Funding Scheme Project Grants

Notes Standard Project Grant

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