Involvement of cell coupling in vascular function: Development of a computational model [ 2006 - 2008 ]

Research Grant

[Cite as]

Researchers Prof CE Hill; Dr F Edwards

Brief description Gap junctions are intercellular channels which enable the production of coordinated responses in multicellular tissues and organs. Blood vessels are comprised of endothelial cells surrounded by smooth muscle cells and gap junctions exist within and between these layers. The present proposal will determine the fundamental role of gap junctions in regulating blood flow and blood pressure. Our data will enable us to develop a computational model of the vascular wall and so predict how changes in electrical properties, as occur during pressure changes, can influence blood flow. Since ageing is accompanied by an increase in blood pressure, our results will contribute to a better understanding of blood flow regulation in our ageing population.

Funding Amount $275,000

Funding Scheme Discovery Projects

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