[Cite as http://purl.org/au-research/grants/arc/LP130100531]
Researchers Prof Paul Gleeson; Dr Anne Verhagen; Prof Steven Dower;
Brief description The so-called neonatal IgG Fc receptor (FcRn) protects IgG and albumin from intracellular degradation and plays a critical role in prolonging the half-life of these serum proteins in adults. FcRn binds to its ligands in acidic endosomal compartments and then recycles bound ligands back to the cell surface for release into the circulation. There is considerable potential to exploit the activity of FcRn to enhance the half-life of therapeutic proteins for treatment of human disease by the inclusion of FcRn binding sites in recombinant proteins. Here we will define the intracellular itinerary of FcRn and analyze the intracellular ligand-FcRn interactions.
Funding Amount 495000
Funding Scheme Linkage Projects