[Cite as http://purl.org/au-research/grants/arc/LP140100711]
Researchers Prof Mark Willcox; Prof Stephen Blanksby; A/Prof Todd Mitchell; Dr Michael Kelso; Prof Thomas Millar; Dr Simon Brown; Dr Peter Simmons; Dr Joseph Vehige
Brief description The tear film lipid layer covers the eye, stabilises the tears and prevents their evaporation. Yet its structure, function and composition is yet to be fully elucidated. The aim of this project is to fully characterise the unique lipids in this layer, the long-chain omega-hydroxy fatty acids (not found elsewhere in the body), and to determine their role in its structure and function. The project is significant because the unique combination of skills of the CIs and PIs (synthetic chemistry, mass spectrometry, lipidomics, biochemistry, biophysics) will result in a major shift in our understanding of this layer and production of high impact publications in a variety of disciplines (chemistry, biochemistry, vision science).
Funding Amount 450000
Funding Scheme Linkage Projects