[Cite as http://purl.org/au-research/grants/arc/LP140100967]
Researchers Prof Katharina Gaus; Dr Philip Nicovich; Dr Luciano Guerreiro Lucas
Brief description It is now possible to record the positions of single fluorescent molecules in intact cells to build up an image literally molecule by molecule. But how to ‘connect the dots’ and extract structural information from molecular coordinates is yet to be worked out. We will do exactly that, and write and implement novel analysis routines to quantify a diverse range of biological structures such as protein complexes, membrane morphologies, filamentous cytoskeletal networks, vesicles and viruses. The project is a collaboration between a cell biologist (Gaus) who is a leader in single molecule localisation microscopy, an expert in fluorescence image analysis (Nicovich) and an industry partner (Lucas) who has a sophisticated software platform.
Funding Amount 386372
Funding Scheme Linkage Projects