[Cite as http://purl.org/au-research/grants/arc/LP160100325]
Researchers A/Prof Vincent Wallace; Prof Charles Bond; Dr Robert Falconer; Dr Christopher van der Walle; Dr Philip Taday
Brief description This project aims to develop advanced terahertz time-domain spectroscopy (THz-TDS) techniques to understand how a protein’s interaction with excipients in solution can alter the hydration layers around them and how this affects properties such as viscosity and stability. THz-TDS can detect overlapping extended hydration layers around proteins, revealing new knowledge in protein-protein interactions and protein behaviour in an aqueous environment. The intended outcome is to use THz-TDS to better understand how proteins such as monoclonal antibodies interact in high concentration solutions, and in doing so make better medicines.
Funding Amount $270,000
Funding Scheme Linkage Projects