grant

Microparticles and Selective Trait Dominance in Multidrug Resistant Cancers [ 2011 - 2013 ]

Also known as: Selective Trait Dominance in Cancer

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1007613]

Researchers: A/Pr Mary Bebawy (Principal investigator) Dr Valery Combes Prof Georges Grau (Participant)

Brief description Multidrug resistance (MDR) is the cause of treatment failure in 90% of patients with metastatic cancer. We recently discovered a novel resistance mechanism in which microparticles provide a vehicle for intercellular transfer of MDR. We now report that MP play an even more significant role in conferring MDR, by the ñre-templatingî of cancer cell traits. This has considerable potential for translation into clinical outcomes with the identification of alternative drug targets and therapeutics for the circumvention of MDR clinically.

Funding Amount $AUD 478,115.76

Funding Scheme Project Grants

Notes Standard Project Grant

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