Myo1b bridges the actin-membrane interface during osteoclastic bone resorption [ 2012 - 2014 ]

Also known as: Characterisation of structural protein Myo1b in bone-resorbing cells

Research Grant

[Cite as]

Researchers: A/Pr Nathan Pavlos (Principal investigator) ,  Prof Jiake Xu Prof Minghao Zheng

Brief description Osteoporosis is a debilitating bone disease which features progressive bone loss. Bone loss (resorption) is driven by the bone resident cell the osteoclast. Identifying molecules that regulate bone resorption by osteoclasts is a crucial first step towards developing new targets for theraputic intervention. This proposal explores the role of Myo1b, a novel protein that appears to facilitate osteoclastic bone resorption and thus represents an attractive new candidate to target bone loss.

Funding Amount $AUD 429,387.56

Funding Scheme Project Grants

Notes Standard Project Grant

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