grant

NT-3 as an upstream and potentially master regulator promoting bone fracture healing [ 2017 - 2018 ]

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1127396]

Researchers: A/Pr Bruce Foster Prof Jiake Xu (Participant) Prof Cory Xian (Principal investigator)

Brief description There is a strong clinical need for cost-effective treatments for delayed healing or non-union bone fractures. Our recent data suggest injury site-derived neurotrophin-3 (NT-3) may be an important overall regulator of bone repair by inducing key factors involved in fracture callus formation and remodelling. This project will address roles and mechanisms of endogenous NT-3 in bone repair and the likelihood of exogenous NT-3 protein in promoting bone healing in clinically relevant fracture models.

Funding Amount $AUD 729,796.43

Funding Scheme Project Grants

Notes Standard Project Grant

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