grant

Repurposing Amiloride into Breast Cancer Drugs with a Dual-Targeting Mechanism [ 2016 - ]

Also known as: 5015656

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/GNT1100432]

Researchers: A/Pr Michael Kelso (Principal investigator) ,  Prof Marie Ranson Prof Mingdong Huang

Brief description This project aims to transform a diuretic drug (amiloride) into a breast cancer drug that acts via a novel molecular mechanism. The science of medicinal chemistry will be used to remove amiloride's diuretic effects whilst gaining potent dual-activity against two breast cancer targets, uPA and NHE1. Our study will validate a new pharmacological approach in cancer treatment and produce patented drugs suitable for development into first-in-class breast cancer drugs.

Funding Amount $611,966.00

Funding Scheme Project Grants

Notes Standard Project Grant

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