grant

Reversal of diabetes in a humanised mouse using a clinically applicable vector system [ 2015 - 2018 ]

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1086256]

Researchers: A/Pr Bronwyn O'Brien Prof Ian Alexander (Participant) Prof Ann Simpson (Principal investigator)

Brief description Somatic gene therapy is one of the strategies that is being considered to cure Type I diabetes. Specifically, we wish to engineer liver cells to replace beta cell function. The aim of this project is to design a clinically-applicable protocol for the reversal of diabetes using a recombinant adeno-associated vector that delivers genes to human livers with high efficiency showing long term expression without pathogenicity and immunogenicity following a simple intra-peritoneal injection.

Funding Amount $AUD 842,173.28

Funding Scheme Project Grants

Notes Standard Project Grant

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