grant

Risk factors, screening, prophylaxis and outcomes in individuals from breast cancer families: kConFab Follow-Up Study [ 2004 - 2006 ]

Also known as: kConFab Clinical Follow-Up Project

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/288704]

Researchers: Prof Kelly-Anne Phillips (Principal investigator) ,  A/Pr Sue-Anne Mclachlan Prof Geoffrey Lindeman Prof Mark Jenkins Prof Michael Friedlander

Brief description Having a strong family history of breast cancer is one of the most important risk factors for the disease. Two major genes, BRCA1 and BRCA2, have been identified which, when abnormal, result in an inherited tendency towards developing breast cancer. Women with a strong family history of breast cancer can undergo testing for these gene abnormalities via Family Cancer Centres around Australia. However, once a gene abnormality is found, little is known about the best ways to prevent cancer or detect it early. The Kathleen Cuningham Consortium for Research into Familial Aspects of Breast Cancer (kConFab) has been recruiting families with exceptionally strong histories of breast cancer since 1997. kConFab is funded to collect epidemiological information and biological specimens on such individuals only at the time of their initial recruitment. In 2000 the NHMRC recognised the importance of undertaking clinical follow-up of this precious cohort of individuals, and provided funding through a 3 year project grant to commence the first round of 3 yearly follow-up on this cohort (NHMRC Project Grant #145684). The first 2 years of this follow-up has been completed successfully and the current is application is for a renewal of funding (to commence in 2004) to enable us to undertake further follow-up of the now much larger cohort. In the short term we will examine the screening and preventive surgery behaviours of high risk women within this study to determine whether they are optimal. The ultimate aim of this long term follow-up of individuals in kConFab is to determine what factors impact on the development of cancer in well individuals with a genetic predisposition to breast cancer.

Funding Amount $AUD 510,675.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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