The role of connexins in blood pressure regulation: Use of a conditional gene expression system [ 2008 - 2011 ]

Also known as: Regulation of blood pressure by cell coupling

Research Grant

[Cite as]

Researchers: Prof Caryl Hill (Principal investigator) ,  Prof Klaus Matthaei

Brief description Cell coupling through gap junctions is said to play an important role in regulating blood flow and blood pressure. However data obtained from mice, in which specific gap junctions are deleted, may be compromised by compensatory changes in other junctions. We have validated a new method for rapidly and reversibly altering gap junctions in adult mice with oral sugar. This technique will enable us to directly determine whether interference with cell coupling affects blood flow and blood pressure.

Funding Amount $AUD 583,767.21

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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