[Cite as http://purl.org/au-research/grants/nhmrc/569735]
Prof David Fairlie
Prof Matthew Sweet
Brief description HDAC inhibitors are anti-cancer drugs that kill rapidly growing cells (like cancer cells). These drugs also have anti-inflammatory properties and so may be beneficial in chronic inflammatory diseases such as as Rheumatoid Arthritis. However, it is unknown how they reduce inflammation. In this project we aim to understand how HDAC inhibitors act as anti-inflammatory agents and to design new HDAC inhibitors with reduced side effects for the treatment of inflammatory diseases.
Funding Amount $AUD 581,892.59
Funding Scheme NHMRC Project Grants
Standard Project Grant