grant

Targeting histone deacetylases 1 and 5 to reduce inflammation and bone loss in periodontitis. [ 2014 - 2017 ]

Also known as: HDAC 1 and 5 in Periodontitis

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1057835]

Researchers: Prof David Haynes (Principal investigator) ,  Dr Melissa Cantley Prof Mark Bartold

Brief description Bone loss and tooth loosening are serious complications in periodontitis. Despite the prevalence of this disease current treatments do not directly stop the bone loss. Our recent laboratory studies show inhibiting histone deacetylase (HDAC) activity with very low doses of inhibitors can effectively suppress this bone loss in periodontitis. This project aims to investigate specific targeting inhibitors of HDAC 1 and HDAC 5 to treat periodontitis by enhancing bone formation and reducing bone loss.

Funding Amount $AUD 536,745.07

Funding Scheme Project Grants

Notes Standard Project Grant

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