[Cite as http://purl.org/au-research/grants/nhmrc/1053195]
Dr Anthony Cesare
Brief description Following genome damage cells stop the cell division process and initiate DNA repair. We discovered that at specific times during cell division his does not happen if the damage signals originate from the chromosome ends (i.e. “telomeres”). We anticipate this is necessary to prevent genomic instability in healthy cells and may be driving genomic instability in cancer cells. Experiments described here will elucidate the molecular mechanisms and biological significance of our observation.
Funding Amount $AUD 302,627.26
Funding Scheme Project Grants
New Investigator Grant